The cure!!!

Permalink Reply by Nicolas on February 1, 2016 at 6:36pm

Here another article i meet (about t cells)

Highlights

•We prove the safety and feasibility of a two-treatment approach with SCE therapy.
•The percentage of naïve CD4+ and TCM cells were increased, but the percentage of CD4+ TEM and CD8+ TEMcells were declined.
•The expression of CCR7 on naïve T and TCM cells were markedly increased.

The current studies demonstrated the safety and feasibility of a two-treatment approach with Stem Cell Educator therapy and well tolerated in all subjects, without significantly changing the numbers and ratios of different cell compartments in the subjects' immune system. Both the percentage of CD4+ and CD8+ effector memory T cells were substantially decreased in the peripheral blood of T1D subjects, whereas the percentage of CD4+ central memory T cells was markedly and constantly increased. These findings provide a solution to alter the autoimmune memory compartment in T1D, while mitigating safety and ethical concerns associated with conventional immune therapies.

Abstract

Background

Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease that causes a deficit of pancreatic islet β cells. The complexities of overcoming autoimmunity in T1D have contributed to the challenges the research community faces when devising successful treatments with conventional immune therapies. Overcoming autoimmune T cell memory represents one of the key hurdles.

Methods

In this open-label, phase 1/phase 2 study, Caucasian T1D patients (N = 15) received two treatments with the Stem Cell Educator (SCE) therapy, an approach that uses human multipotent cord blood-derived multipotent stem cells (CB-SCs). SCE therapy involves a closed-loop system that briefly treats the patient's lymphocytes with CB-SCs in vitro and returns the “educated” lymphocytes (but not the CB-SCs) into the patient's blood circulation. This study is registered with ClinicalTrials.gov, NCT01350219.

Findings

Clinical data demonstrated that SCE therapy was well tolerated in all subjects. The percentage of naïve CD4+ T cells was significantly increased at 26 weeks and maintained through the final follow-up at 56 weeks. The percentage of CD4+ central memory T cells (TCM) was markedly and constantly increased at 18 weeks. Both CD4+ effector memory T cells (TEM) and CD8+ TEM cells were considerably decreased at 18 weeks and 26 weeks respectively. Additional clinical data demonstrated the modulation of C–C chemokine receptor 7 (CCR7) expressions on naïve T, TCM, and TEM cells. Following two treatments with SCE therapy, islet β-cell function was improved and maintained in individuals with residual β-cell function, but not in those without residual β-cell function.

Interpretation

Current clinical data demonstrated the safety and efficacy of SCE therapy in immune modulation. SCE therapy provides lasting reversal of autoimmune memory that could improve islet β-cell function in Caucasian subjects.

Funding

Obra Social “La Caixa”, Instituto de Salud Carlos III, Red de Investigación Renal, European Union FEDER Funds, Principado de Asturias, FICYT, and Hackensack University Medical Center Foundation.

Keywords:

Type 1 diabetes, Autoimmunity, Memory T cells, Cord blood stem cell, Immune mo

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Permalink Reply by skip on February 1, 2016 at 6:55pm

Alopecia friends... I've been to China twice for this treatment. Once in August of last year (2015) and once over the Thanksgiving holiday (November). To this day I haven't seen any hair improvement from the treatment. Although I did have aches in my feet and knees that had developed over the last several years that disappeared after the first treatment and has never come back. hmmm

I'm a mid 40's guy who has been AU for 5 years. I found out about this treatment last year around June. I immediately contacted several of the doctors one being Dr. Zhao. He's a wonderful man who it completely compassionate to our condition. After many labs and filling out all kinds of release forms I travels to Shijiazhuang China, via Beijing. For all I'd heard about the pollution I was not at all prepared for how bad it was. So sad and depressing. But the people and food were amazing.

The first time I went it was a breeze. It's a three day process all together. On Wednesday I got pre labs to get my blood count so they could calibrate the machine. Thursday I got the treatment which takes from about 8:15am to about 5:30pm. The only pain is that you are laying on your back that entire time. You can go to the bathroom about noon after they take the tube that is taking the blood out of you out of your arm. Otherwise you are on your back.. I'm a side sleeper so this was really REALLY tough. But for hair...anything. I felt a little tired after, but went back to the hotel and slept great. Friday morning I was back to the hospital to get post labs and then you're done.

My second trip was not so easy. About 6 hours into the treatment I starting having an allergic reaction and had to stop. They gave me a quick shot and after about 45 minutes I was back to normal. The doctor said I probably got 80% of the treatment that time.

In speaking with the hospital doctor in China (semi through my translator) he said that the girl in the pictures was the best case of all the people they treated. He said it works wonders with diabetes and some other auto immune things...but that every case is different and that it usually takes 3 or more treatments.

I still do think this procedure has promise...and I asked several times if I could do several days while I was there. They were just not comfortable doing that. Personally I think that is how it will work. The more cells that are trained...the more of a chance at reversing the condition.

In the process I spoke with one of the doctors from the cell lab in Florida (can't remember the name off hand) and he said they were really focused on the diabetes angle first. I really have been off the radar on this so I'm not sure what stages the trials are at. All the doctors kept saying that the FDA was being very difficult and that they were going to have to go through a bunch of red tape. (shocker!!).

I don't want to be Debbie Downer... just wanted to share my experience. Happy to answer any questions anyone might have.

Skip

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Permalink Reply by skip on February 1, 2016 at 7:22pm