Julija's Posts - Alopecia World
2024-03-29T13:44:53Z
Julija
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Am lost.. an article for discovering the cause for alopecia areata - alopecia universalis
tag:alopeciaworld.com,2012-01-28:2022678:BlogPost:883122
2012-01-28T20:10:56.000Z
Julija
https://alopeciaworld.com/profile/Julija
<p>A Mouse Model of Clonal CD8+ T Lymphocyte-Mediated Alopecia Areata Progressing to Alopecia Universalis<br></br> Rajshekhar Alli*, Phuong Nguyen*, Kelli Boyd*,†, John P. Sundberg‡ and Terrence L. Geiger*<br></br> + Author Affiliations</p>
<p>*Department of Pathology, St. Jude Children’s Research Hospital, Memphis, TN 38105;<br></br> †Department of Pathology, Vanderbilt University, Nashville, TN 37232; and<br></br> ‡The Jackson Laboratory, Bar Harbor, ME 04609<br></br>
Address correspondence and reprint requests…</p>
<p>A Mouse Model of Clonal CD8+ T Lymphocyte-Mediated Alopecia Areata Progressing to Alopecia Universalis<br/> Rajshekhar Alli*, Phuong Nguyen*, Kelli Boyd*,†, John P. Sundberg‡ and Terrence L. Geiger*<br/>
+ Author Affiliations</p>
<p>*Department of Pathology, St. Jude Children’s Research Hospital, Memphis, TN 38105;<br/> †Department of Pathology, Vanderbilt University, Nashville, TN 37232; and<br/>
‡The Jackson Laboratory, Bar Harbor, ME 04609<br/>
Address correspondence and reprint requests to Dr. Terrence L. Geiger, Department of Pathology, St. Jude Children’s Research Hospital, 262 St. Jude Place, D-4047, Memphis, TN 38105. E-mail address: terrence.geiger@stjude.org<br/>
Abstract</p>
<p>Alopecia areata is among the most prevalent autoimmune diseases, yet compared with other autoimmune conditions, it is not well studied. This in part results from limitations in the C3H/HeJ mouse and DEBR rat model systems most commonly used to study the disease, which display a low frequency and late onset. We describe a novel high-incidence model for spontaneous alopecia areata. The 1MOG244 T cell expresses dual TCRA chains, one of which, when combined with the single TCRB present, promotes the development of CD8+ T cells with specificity for hair follicles. Retroviral transgenic mice expressing this TCR develop spontaneous alopecia areata at nearly 100% incidence. Disease initially follows a reticular pattern, with regionally cyclic episodes of hair loss and regrowth, and ultimately progresses to alopecia universalis. Alopecia development is associated with CD8+ T cell activation, migration into the intrafollicular region, and hair follicle destruction. The disease may be adoptively transferred with T lymphocytes and is class I and not class II MHC-dependent. Pathologic T cells primarily express IFNG and IL-17 early in disease, with dramatic increases in cytokine production and recruitment of IL-4 and IL-10 production with disease progression. Inhibition of individual cytokines did not significantly alter disease incidence, potentially indicating redundancy in cytokine responses. These results therefore characterize a new high-incidence model for alopecia areata in C57BL/6J mice, the first to our knowledge to apply a monoclonal TCR, and indicate that class I MHC-restricted CD8+ T lymphocytes can independently mediate the pathologic response.</p>
<p>Footnotes</p>
<p>This work was supported by National Institutes of Health Grants R01 AI056153 (to T.L.G.) and R01 AR056635 (to J.P.S.), the American Lebanese Syrian Associated Charities/St. Jude Children’s Research Hospital (to R.A., P.N., K.B., and T.L.G.), and the North American Hair Research Society (to K.B.).<br/> The online version of this article contains supplemental material.<br/>
Received March 8, 2011.<br/>
Accepted October 22, 2011.<br/>
Copyright © 2011 by The American Association of Immunologists This is the all text and i copy and past it all as it was now i don't really get the text because all the scientific words, what does retroviral transgenic mice even mean?? Does it mean a mice that had retrovirus and that passed it to the other mice?Sadly i think they mean that, am not sure did look up some retroviruses if this is the case they are contagious and remain in body for life cause all kind of problems and even breast cancer that i didn't even know was a cause from virus and leukemia to now seems for alopecia as well..</p>
My ex had Au now am having weird skin reaction and alopecia
tag:alopeciaworld.com,2012-01-15:2022678:BlogPost:878330
2012-01-15T10:53:46.000Z
Julija
https://alopeciaworld.com/profile/Julija
<p>If anyone know my story i had a bf that had au but now as time go by i got very agresive seborheic dermatitis with scaly eyebrows scalp and painful ear swollen red bit itchy as that went away now i have dry scalp still ,face .But weird part is my eyebrows and pubic area have this pink skin look itchy painful a bit if i pressure it next day whatever this is from my eyebrow it went down my eye making it red and swollen itchy to now is spreading on my nose is pink and itches also i noticed bit…</p>
<p>If anyone know my story i had a bf that had au but now as time go by i got very agresive seborheic dermatitis with scaly eyebrows scalp and painful ear swollen red bit itchy as that went away now i have dry scalp still ,face .But weird part is my eyebrows and pubic area have this pink skin look itchy painful a bit if i pressure it next day whatever this is from my eyebrow it went down my eye making it red and swollen itchy to now is spreading on my nose is pink and itches also i noticed bit like white heads pimples on my eyebrows i have never before have skin problems nor this sort of reactions anyone else has this?Am starting to think is some viral infection herpes or bacteria or fungus anyone got tested for this? Will really appreciate any info and reply thank you</p>
He left. I wish he would come back
tag:alopeciaworld.com,2011-10-09:2022678:BlogPost:827217
2011-10-09T15:00:00.000Z
Julija
https://alopeciaworld.com/profile/Julija
Well if anyone read this i will really appreciate any comment am also new to this well here goes..This is my story i am 20 years old my bf is 27 he has Alopecia Universalis since he was 10 years old first his eyebrow fell and than all the rest.He was always going on doctors to find out more for his condition(bk to my story)We started dating soon after we have meet, we got engaged and started living together for 3 and half years, month a go nightmare happened..He started relation with me only…
Well if anyone read this i will really appreciate any comment am also new to this well here goes..This is my story i am 20 years old my bf is 27 he has Alopecia Universalis since he was 10 years old first his eyebrow fell and than all the rest.He was always going on doctors to find out more for his condition(bk to my story)We started dating soon after we have meet, we got engaged and started living together for 3 and half years, month a go nightmare happened..He started relation with me only when he got sure that his alopecia cant be passed from person to person or to the child if we had any.His alopecia never bothered me he was the only man for me and always will be love him too much but guess it mattered to him, and he wanted to make sure.We had wonderful relation but than one day he got back from work didn't gave me the kiss he always used to, and he looked very devastated asked him what happened he told me that he found on the internet at work that his condition might be from a virus.And that he must end the relation with me..I just stand there and can't believe i heard him saying that i tried to talk to him tell him idc for his alopecia and that i love him i also had 1 more news i wanted to tell him that day that i was pregnant but i didn't, he just said maybe you don't care but i do i wont make you go try the sufferings i did he grabbed some stuff and just went try the door, as fast he could i was in sock of what was happening and fell on the floor and cried try all the night, am crying all the time we talked on the phone few times i tried to make him come back but he said is done that the thing he saw on internet changed everything and that he is doing this because he loves me i even contacted a lot doctors so to give him proof he is wrong. But i got no reply from the emails i sent to docs i feel very tired and idk what to do so come here as hoping someone will read this blog and share info..I also still didn't told him am pregnant because idk how he will react because he don't want me once he saw some site..