I don't live in the States, but I wonder if there is the option of having the topical cream made by a compounding pharmacy. The traditional role of compounding pharmacies is to make drugs prescribed by doctors for specific patients with needs that can't be met by commercially available drugs.
Below is how Dr Christiano describes making the cream in her study. As I understand it, this is for making both a Ruxolitinib version, and a separate Tofacitinib (Xeljanz) version. I don't know if it's a complete instruction set. Presumably, only the compounding pharmacy would be able to determine that.
"Ruxolitinib was purchased from ChemieTek (catalog no. CT-INCB). Tofacitinib was purchased from AbMole BioScience (catalog no. 477600-75-2). Hedgehog agonist (SAG) was purchased from EMD Millipore (catalog no. 566660). JAK-STAT inhibitors were dissolved in DMSO and used at 2 to 3% for in vivo experiments, as indicated, and 400 nM for in vitro experiments. SAG was used at 120 μM, as described by Paladini et al. (2)."
I'm taking part in a clinical trial in Australia next year for JAK inhibtor topical, going to be interesting to see what happens, quite exciting really
Thanks for the posts
That is really nice! By whom is this trial sponsored? Incyte as well? Do you also have a link to the trial and is it a topical form of ruxolitinib as well or is it topical tofacitinib (xeljanz)? I just ask these questions out of curiosity.
On the link I posted they are only recruiting for the States.
Its by an independent clinic trialing both ruxolitinib and tofacitinib topical. It seems there is good options Stateside for trials
If you search online you will find trials in various parts of the States, if thats where you are
Where are you in Australia?