Ruxolitinib

I have been on Ruxolitinib (Jakafi) for 1 month now and have seen some small white hairs on scalp and arms. I have been universalis for about 12 years, I am 22. Dr. King prescribed it on a whim thinking it would not get covered but they did it. My dad is a doctor so I think his health insurance is just good like that. It is called Amerihealth.

I tried xeljanz for 8 months, saw a little regrowth but then it kind of stalled out and faded away. Jakafi seems to be responding much quicker. I am very interested to hear if anyone is on Jakafi or has been. The published studies are so small that its hard to get an accurate read on how the medication works. 

Anyway I will keep everyone posted

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Permalink Reply by Carlie on October 15, 2017 at 7:18pm

Are you still taking the Ruxolitinib and how is the hair coming?

Permalink Reply by ChrisPowers on July 24, 2017 at 5:09pm

My dermatologist was willing to prescribe it until this article was published:

https://www.ncbi.nlm.nih.gov/pubmed/28628689

"Aggressive Skin Cancers Occurring in Patients Treated With the Janus Kinase Inhibitor Ruxolitinib"

As a result, he no longer feels that the potential for benefit outweighs the risk with this medication.  That's unfortunate, of course, but so is aggressive malignancy.

I discontinued Xeljanz for the same reason as Joey--it stalled, even after raising the dose to 20mg / day.  I also suspect that it might have been responsible for some symptoms I developed such as fatigue and anemia, but that's difficult to know for certain.

I'm curious what the long-term results will be for someone who was an inadequate responder to Xeljanz, but make sure you're checking out your skin regularly, and have your dermatologist do the same.

Permalink Reply by LIU CHUNXIU on July 24, 2017 at 9:12pm
could you please post the full paper?
Permalink Reply by ChrisPowers on July 25, 2017 at 2:12pm

Here you go.

Attachments:
Permalink Reply by Patchesforlife on July 26, 2017 at 12:39am
Please keep us posted!
Permalink Reply by Patchesforlife on July 26, 2017 at 1:06am
Hi Joey. Can you please ask Dr. King when doe he think fda will approve drugs for alopecia?
Permalink Reply by singh on July 26, 2017 at 4:14pm
Hi joey could you show dr King this article Chris has postered and see what his opinion is on it ?

I personally think looking at it there a lot of factors such as there all 5 patients of age, and they seem to have had high dosage of other treatment before taking ruxonlitnib. A couple of them seem to be exposed to the sun which could of aggregated it.

And finally they have all have mylofibrosis.

So would be great to find out what dr King feels about it .

Thank you

Kind regards
Permalink Reply by Nykodym on November 5, 2017 at 1:22pm

I don't know rules of this forum but ...

Maybe someone have used (open) box Ruxolitinib for sale.

I am from Ukraine, but have post adress in US.

Thanks.

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